Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402

Biotechnology Letters 2005 Jun; 27(12):835-8

School of Life & Environmental Science, Wenzhou University, Wenzhou, China

Ganoderic acid (GA), produced by submerged culture of Ganoderma lucidum, at 500 μg/ml, caused nearly a 70% inhibition of the growth of human hepatoma cell line BEL7402 but not of a normal human liver cell line L02. Flow cytometry analyses showed that GA blocked the BEL7402 cell cycle at the transition from G1 to S phase.

PMID: 16086244 [PubMed – indexed for MEDLINE]